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Showing posts from September, 2017

Cancer-What If

Tumor heterogeneity-Different tumor cells having altered ratios of tumor suppressing to tumor promoting activity, alters signaling networks in space and time.
Cancer-Impairement in restoration of homeostasis(2nd hit/microenvironment related)) in primary hit (tumor suppressor inhibiting/oncogene activating) cells.
Metaphor/Visualization-Ist mutational hit. Cells tries to restore homeostatic balance. Fails to optimize.=Second hit (tumor microenvironment interactions)-Tumor metastasis.
Like an oscillating pendulum that overshoots mean position once. Comes back to mean balance position. Overshoots the Ist extreme position due to loss of elasticity of string (when failing to optimize lost mean position/Youngs Modulus/Hooks Law). Loss of elasticity. status quo of extreme position maintained. equivalent to tumorigenesis.
Fractals-Self similar patterns of related tumor suppressing and tumor promoting signaling networks.
in a normal cell. Fractal pattern of signaling networks altered in a tum…

Meditation-Sankhya Yoga-Yoga Psychology Based on Experience

The Rishis (Sages) of the past meditated. They included both men (eg Kapila) and women (eg Gargi).
By meditate I mean concentrated focus/observation of their own psychical system.
Meditation is a systems approach.  The rishis went from the surface layers of the mind to probe into deeper levels. The self (atman) is the  unaffected  indivisible witness/seer underlying the split/multiple psycho (buddhi/intellect)-physical (manas/mind) system. The body is multicellular , including the brain (consisting of the sensory input processing system/manas). Under normal circumstances, in a conditioned human, the physical predominates i.e data arriving from the sense organs (eyes, ears etc) onto the manas. In a  thinking mind, intelligence of the buddhi (determinative faculty psychical) is reflected on the manas (physical/cogitating mind) and memory (chitta-memory bank/impressions) develops. Anger,jealousy,greed etc predominate when the discriminatory/determinative capacity (buddhi) ceases. The  4…

The difference between winning and succeeding | John Wooden

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ABBA : I Have A Dream, HD

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Westlife - I Have A Dream (With Lyrics)

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Karunesh-Endless skies

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The Brain with David Eagleman - What Is Reality - BBC Documentary 2016

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Amar Mukti

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